What is cannabidivarinic acid (CBDVA)?

What is cannabidivarinic acid (CBDVA)?

Cannabidivarinic acid (CBDVA) is a noteworthy cannabinoid found within the intricate chemical profile of the cannabis plant. As a precursor to cannabidivarin (CBDV), CBDVA is part of the acidic form of cannabinoids that undergoes decarboxylation to convert into its active form.

While much of the spotlight has been on cannabinoids like THC and CBD, CBDVA represents a growing area of interest for researchers exploring the full spectrum of compounds that cannabis offers. The study of CBDVA encompasses understanding its biosynthesis, chemical structure, and potential therapeutic applications.

Preliminary research suggests that CBDVA, like other cannabinoid acids, may possess unique properties that could contribute to its use in medical and wellness contexts. As the scientific community continues to unravel the complexities of cannabinoids, CBDVA’s role in the broader cannabis ecosystem is becoming increasingly significant, pointing to the plant’s vast potential to provide diverse health benefits and advancing cannabinoid science.

Key takeaways

  • Cannabidivarinic acid (CBDVA) is a non-psychoactive cannabinoid found in cannabis.
  • CBDVA shares anti-inflammatory properties akin to those of other well-known cannabinoids.
  • It can be accurately measured using techniques such as GC/MS, LC/MS, and HPLC.
  • Research on CBDVA is crucial for understanding its potential therapeutic applications.
  • CBDVA’s non-psychoactive nature makes it an attractive candidate for various medicinal research projects.

Introduction to cannabidivarinic acid

Let’s start by looking at cannabidivarinic acid (CBDVA). This acid is non-psychoactive and comes from the cannabis plant. Although found in 1977, it has only recently sparked interest.

CBDVA got little attention until about 2010. This is especially true when you compare it to popular cannabinoids like CBD and CBDV. It is rare to see CBDVA in products for consumers. Right now, its biggest use is in research, particularly to study its effect on epilepsy.

People are more curious about CBDVA because it might help with health issues. Early research suggests it might fight inflammation, nausea, and seizures. A 2020 review even talks about its possible role in protecting our brain cells. This makes it interesting to make new medicines to help with brain conditions and seizures.

Even though CBDVA might be very helpful, it is hard to use in everyday products. This is because it is not easily found and the extraction method is tricky. If you heat CBDVA too much, it changes into CBDV. This means we need to be careful how we use it to get the best effects.

Some people like to drink fresh cannabis juice. This way, they avoid changing CBDVA into something else. Also, some scientists are working on using yeast to make CBDVA. This could make it easier to get medicine in the future.

What makes CBDVA unique is its structure. It stands out from other cannabinoids because of this. It may be good for helping with problems like joint pain, multiple sclerosis, and gut issues because of its anti-inflammatory properties.

CBDVA does not make you feel high, unlike THC. This makes it suitable for people who want health benefits without getting high. It could be used in many different health and therapy products.

Even though we have more to learn about CBDVA, its possible uses are very exciting. As more studies are done, we might find new ways to use CBDVA. This could lead to more treatments and scientific discoveries.

Chemical structure and composition of CBDVA

The CBDVA chemical structure is key to knowing about its traits and potential uses. It’s made up of different parts that give it its unique form. You can find this compound in specific types of cannabis plants.

Chemical formula

CBDVA’s chemical formula is C20H26O4. This shows it has 20 carbon, 26 hydrogen, and 4 oxygen atoms. The formula explains CBDVA’s makeup clearly and simply.

CAS number and molecular weight

CAS numbers are special IDs for chemicals. CBDVA’s CAS number is 31932-13-5. Its molecular weight is 330.42 grams per mole. This info helps with studying and making CBDVA in labs.

The origin of cannabidivarinic acid in the cannabis plant

CBDVA was founded in 1977, which was a big step in exploring cannabis. Since the 1960s, research has looked into where cannabinoids come from. This has shown the complex chemistry of different cannabis plant types. Looking at minor cannabinoids like CBDVA helps us see if they could be helpful medically.

Cannabis plant on a farm

Plant species containing CBDVA

Cannabis sativa is one type of cannabis that naturally has CBDVA. Growers value these types for their special range of cannabinoids, including CBDVA. These strains are interesting for their possible health uses. A key phytocannabinoid in Cannabis sativa L., Δ9-tetrahydrocannabiphorol, shows strong activity in the body. This points to how these compounds work together in the plant.

Natural occurrence and synthesis

CBDVA comes from natural processes inside the cannabis plant. By studying minor cannabinoids, we’ve discovered new cannabis components. Some of these, like cannabidihexol, could have medical benefits. Scientists use tools like gas chromatography-mass spectrometry to analyse these compounds. They’ve found that the amount and type of these chemicals change between parts of the plant.

Even the stems and roots of cannabis have unique chemicals. Studies have found that grinding cannabis by hand gives better results than with a machine. This process can also make CBDVA for research use, making studies more accurate.

Though not as well-known as THC and CBD, CBDVA is becoming more studied. This helps us learn more about the cannabis plant.

What is cannabidivarinic acid (CBDVA)?

Cannabidivarinic acid (CBDVA) is a compound in the cannabis plant. It’s getting attention for its possible health benefits. It’s different from some other compounds because it doesn’t get you ‘high’. This is exciting for researchers because it means new medical treatments might not have the ‘high’ effect.


Close-up of a cannabis flower on a light blue background

CBDVA might help fight against swelling since it has anti-inflammatory powers. This means it could be good for health issues that involve swelling. As more people look into the power of compounds in cannabis, non-psychoactive ones like CBDVA are getting a lot of interest.

But CBDVA isn’t just interesting for its possible health uses. Scientists and doctors want to figure out the best ways to use it. With the focus now on compounds that don’t make you ‘high’, CBDVA is becoming a key area for research.

CBDVA has a lot of promise, especially in fighting inflammation. It’s important in ongoing research because it’s safe to use without worrying about getting ‘high’. This makes it a key part of medicine based on cannabis.

CBDVA vs. other cannabinoids

Exploring the world of cannabinoids highlights unique traits that set each compound apart. This article explores into the differences between CBDVA, CBD, THC, and CBDV. It focuses on how each affects the human body distinctly.

Comparisons with CBD, THC, and CBDV

CBDVA stands out due to its unique chemistry and behaviours. When we look at CBDVA versus CBDV, we see a crucial distinction. CBDVA has a varinic acid form, while CBDV features a shorter propyl side chain. This difference affects how they bind with receptors and their medical potential.

Unlike THC, CBDVA doesn’t cause a high. This was proven by Guy et al. in their research. While both interact with the endocannabinoid system, they do so in different ways. CBDVA’s interaction doesn’t lead to the psychoactive effects THC does.

Studies on CBDVA are shedding light on new medical uses. In 1996, Taura et al. outlined the process for extracting cannabidiolic-acid synthase. This step has helped researchers better understand the medical potential of these forms.

Because of its non-psychoactive nature, CBDVA could be important in treating conditions. Research continues into how this compound can assist medically. This area is growing, with more clinical trials and studies underway.

The table below outlines the main differences and similarities between CBDVA, CBD, THC, and CBDV:

CannabinoidChemical structurePsychotropicPotential benefits
CBDVAVarinic acid formNoAnti-inflammatory, neuroprotective
CBDVPropyl side chainNoAnxiety, neurological conditions
CBDPentyl side chainNoWide range of therapeutic uses
THCPentyl side chainYesPain relief, anti-nausea

Potential benefits of CBDVA

Many studies and personal stories show cannabidivarinic acid (CBDVA) might help many people. It doesn’t make you ‘high’. It seems to help with different health issues. This is very exciting for the future of medicine.

Anti-inflammatory properties

CBDVA is known for fighting inflammation. This is good news for those with arthritis. Research suggests it can reduce swelling effectively. In tests with mice, CBDVA cut down swelling without bad side effects. This shows promise for both creams and pills to fight inflammation well.

Other potential therapeutic uses

Besides inflammation, CBDVA might also help with seizures. Some studies show it can manage severe epilepsy by affecting certain receptors. It’s also being looked at for protecting the brain. Early signs suggest it might help against brain diseases without causing a ‘high’. This makes it very appealing for medical use.

CBDVA, though not high-inducing, may show up in drug tests sometimes. This is because it’s similar to substances like THC. Yet, efforts are being made to tell them better apart.

As researchers learn more about CBDVA, it could do wonders in medicine. It might help with pain and inflammation, and it can be used safely as a painkiller. Some companies are starting to use CBDVA. But, getting enough is a bit tricky because of how limited it is in nature.

CBDVA effects on the human body

In cannabis research, the focus shifts to non-psychoactive cannabinoids. These show promise for health benefits without the ‘high’ from compounds like THC. A key compound here is cannabidivarinic acid (CBDVA).

Non-psychoactive nature

CBDVA stands out as non-psychoactive. This is very important for people wanting health relief without THC’s highs. Studies have begun to highlight the potential benefits of CBDVA.

Cannabis leaf for medical purposes and non-psychoactive

Back in 1988, a study shone a light on CBDVA’s potential against seizures. It doesn’t change how you think or feel, making it good for medical use. This sets it apart from THC. Cannabis has a history of aiding epilepsy, especially with CBD. Now, we’re finding that compounds like CBDVA are also worth exploring. CBDVA’s non-psychoactive nature makes it a valuable research topic for its possible benefits.

Studies in mice with Dravet, a severe form of epilepsy, are promising. They show how compounds like CBGA, CBDVA, and CBGVA might help manage seizures. This research could lead to new treatments.

CBDVA was discovered by Japanese researchers in 1977, and by 1988 its usefulness against seizures was clear. It’s not yet out for sale, but researchers are working to make it more available. They’re looking at its connection to CBDA and its potential health benefits.

CBDVA is a key, non-psychoactive cannabinoid for health. It could be big for fighting inflammation and seizures. Even though it’s found in hemp in small amounts, it’s being researched for its possible health perks. As more research happens, CBDVA looks to be important in non-psychoactive treatment. It could offer relief without the unwanted side effect of feeling ‘high’.

Current research on CBDVA

Current CBDVA research shows exciting signs for medical uses. It stands out from well-known cannabinoids like CBD and THC. However, CBDVA is still not studied enough. We need to learn more about its effects and healing properties.

Clinical trials and studies

Many clinical trials are looking into CBDVA. They’re checking its impact on health issues such as swelling, epilepsy, and brain disorders. Early signs are positive, but we need bigger, more thorough trials to confirm its benefits.

Scientists doing a clinical study and research about CBDVA and its potential health benefits.

Research gaps and future directions

However, there are still big holes in CBDVA research. Studies often have small samples or don’t last long enough. They also don’t cover enough ground. We need to look into its long-term effects, the best dosages, and how it might mix with other meds. Filling these knowledge gaps will help us find new ways to heal with CBDVA.

AspectCurrent findingsFuture directions
Anti-inflammatory EffectsEarly findings look good, but we need more big trials.We must do longer, more in-depth studies.
Epilepsy treatmentEarly data hints at helpful effects.We should check its use with more people.
Neurological disordersWe’ve found some early, positive leads.Now, we need larger, more detailed studies.

Methods of CBDVA extraction

Obtaining cannabidivarinic acid, or CBDVA, demands careful techniques. It’s important to secure its purity and strength. We’ll explore the extraction methods for CBDVA. Both for testing and for products sold.

Techniques such as GC/MS, LC/MS, and HPLC

For extracting and studying CBDVA, refined chromatography techniques are key. GC/MS analysis, LC/MS, and HPLC are vital. They ensure we can accurately gauge CBDVA’s content.

GC/MS analysis is a mix of gas chromatography and mass spectrometry. It excels in spotting substances in a mix. This makes it perfect for CBDVA. HPLC, on the other hand, helps achieve optimal purity levels by sorting, recognizing, and measuring each part in the mix.

Commercial extraction processes

With a growing market, extracting CBDVA commercially is now a big industry. Processes are set to be both exact and effective. A top pick is using supercritical CO2. This method isolates CBDVA while keeping its purity intact.

Another route is using solvents like ethanol or butane for extraction. These ensure a reliable and high-quality CBDVA output. This makes CBDVA suitable for many sectors.

Employing advanced techniques, like CBDVA extraction through GC/MS analysis and HPLC, is crucial. Not only for research but also for the expanding commercial scene of CBDVA and its products.

Application of CBDVA in testing and profiling

In cannabis testing, cannabidivarinic acid (CBDVA) is very important. It helps us understand cannabis products better. And it shows us how the cannabis plant makes these important compounds. Knowing and measuring these components is key for quality and making medicines.

CBDVA on a flask for testing and profiling

Cannabis potency testing

To test cannabis strength, experts look at different cannabinoids, like CBDVA. They use gas and liquid chromatography. These methods can precisely find how much CBDVA is in cannabis. Cerilliant makes a precise CBDVA standard, which helps get accurate results.

Tests show that different cannabis types have varying amounts of CBDV. They range from 6.3 to 114.9 μg/g. This, along with THC (57.6–407.4 μg/g) and CBD (1.2–8.9 μg/g) levels, gives a full view of product information.

Pharmaceutical research and development

Pharmaceutical studies are quickly exploring CBDVA’s possible medical uses. They’re using advanced methods to see how it works. One new study heats CBDVA to 110°C for an hour to make it easier to analyse.

Getting CBDVA’s profile right is crucial for medical research. A CBDVA standard from Sigma-Aldrich is key for this. It helps researchers work on new medical uses.

Yet, getting accurate data on cannabinoids in different strains is hard. To deal with this, experts use advanced methods for in-depth analyses. For example, one study identified various cannabinoids in serum using advanced techniques.

Empirical formulaC20H26O4
Molecular weight330.42
CAS number31932-13-5
Concentration1.0 mg/mL in acetonitrile
TechniquesGas chromatography (GC), Liquid chromatography (LC)
ApplicationCannabis testing
Quality levelCertified reference material, grade 300
FormatLiquid, single-component solution
Storage temperature-70°C

Using precise analysis helps move medical research forward. CBDVA testing improves medical uses for cannabis. This could open new doors for medical treatments.

Storage and handling of CBDVA

The proper storage and handling of cannabidivarinic acid (CBDVA) are key to keeping it effective in research and commercial uses. It should be kept at very low temperatures, usually in an ultra-freezer. This ensures it lasts a long time. The fragile nature of cannabinoids means they can lose potency if not stored correctly.

To handle CBDVA, certain rules must be followed. It’s interesting that CBDVA may not need as many strict regulations as other substances, at least in terms of the US Drug Enforcement Administration. Even in Canada, there are special rules for CBDVA, making it easier to use in research. Knowing these specific rules helps make using CBDVA in healthcare and pharmaceuticals smoother.

Using modern ultra-freezers for CBDVA storage points to the importance of high-tech labs. Keeping it at the right temperature is crucial for its medical benefits. This is especially true as we discover more about how CBDVA can help in treating inflammation, nausea, and seizures. So, proper storage and handling are vital to keep CBDVA’s effects just right.

Personal insight

As a seasoned veteran when it comes to the CBD industry, I find the topic of cannabidivarinic acid (CBDVA) particularly compelling. This non-psychoactive cannabinoid, found in the cannabis plant, represents a promising frontier in cannabinoid research. My experience has shown that the acidic precursors of cannabinoids, like CBDVA, play a crucial role in the plant’s therapeutic potential.

CBDVA, in particular, has shown potential anti-inflammatory and neuroprotective properties, making it an intriguing candidate for treating conditions such as epilepsy and chronic pain. The scientific community’s growing interest in CBDVA shows the importance of understanding and utilising the full spectrum of cannabinoids.

Early research suggests that CBDVA may help with inflammation, nausea, and seizures, pointing to its significant therapeutic potential.  This cannabinoid’s non-psychoactive nature further enhances its appeal for medical applications, providing patients with the benefits of cannabis without the associated high.

As we continue to uncover the properties and benefits of cannabinoids like CBDVA, I am optimistic about the future advancements in cannabis-based therapies that can enhance patient care and overall well-being.

Frequently asked question

What is cannabidivarinic acid (CBDVA)?

CBDVA is a non-psychoactive compound found in cannabis. It’s like other cannabinoids but doesn’t change the mind. CBDVA’s key feature is its possible help against swelling.

How does CBDVA differ from CBDA?

CBDVA differs from cannabidiolic acid (CBDA) by having a propyl side chain instead of a pentyl side chain, which may affect its pharmacological properties.

What are the potential therapeutic benefits of CBDVA?

The potential therapeutic benefits of CBDVA are still under research, but it may have anti-inflammatory, anticonvulsant, and neuroprotective effects.

How is CBDVA produced in the cannabis plant?

CBDVA is produced in the cannabis plant through the enzymatic conversion of cannabigerovarinic acid (CBGVA).

What is the legal status of CBDVA?

The legal status of CBDVA varies by country and region, generally governed by the same regulations as other cannabinoids derived from cannabis.

Can CBDVA be detected in drug tests?

CBDVA can be detected in drug tests using specialised analytical techniques like mass spectrometry, but it is not commonly included in standard drug screening panels.

How does CBDVA compare to other minor cannabinoids?

CBDVA, like other minor cannabinoids, is present in smaller quantities in the cannabis plant and is less studied, though it may offer unique therapeutic benefits.

Can CBDVA be synthesised in a laboratory?

Yes, CBDVA can be synthesised in a laboratory using chemical synthesis or biosynthesis methods.

What are the potential side effects of CBDVA?

The potential side effects of CBDVA are not well-documented due to limited research, but they may include mild gastrointestinal discomfort or allergic reactions.

What are the potential applications of CBDVA?

Potential applications of CBDVA include its use in pharmaceutical formulations for treating conditions like epilepsy, inflammation, and neurodegenerative diseases.

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